Asian Research Journal of Gynaecology and Obstetrics <p style="text-align: justify;"><strong>Asian Research Journal of Gynaecology and Obstetrics</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/ARJGO/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Gynaecology and Obstetrics’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> <p style="text-align: justify;">&nbsp;</p> Asian Research Journal of Gynaecology and Obstetrics en-US Asian Research Journal of Gynaecology and Obstetrics Giant Uterine Fibroid: A Case Report of a Young Nulliparous Woman and Literature Review <p>Uterine leiomyoma, which arises from uterine smooth muscle, is the most common benign gynaecologic tumour of the female pelvis, however, giant fibroids are very rare in current practice, posing a management challenge. A 28-year-old nulliparous woman presented in a private clinic in Makurdi, Benue State, Nigeria with severe pain and slow growing abdominal mass with pressure symptoms due to a giant uterine fibroid. Intraoperatively, the mass was huge, weighed 11.6kg, was continuous with the uterus and tightly occupied the abdominal cavity with restricted mobility. Myomectomy was done after consideration of the patient’s wishes, fertility concerns and intra operative findings. Patient did well without complications and was discharged on day six.</p> Michael Tyodoo Maanongun Andrea Avershima Ornguze Babarinde Ojo ##submission.copyrightStatement## 2021-03-26 2021-03-26 1 6 The Correlation of the Lipid Profile and Endothelin-1 with Severe Preeclampsia <p><strong>Aims: </strong>To determine the relationship of lipid profile and Endothelin-1 (ET-1) in a severe preeclamptic pregnancy.</p> <p><strong>Study Design:</strong> An observational analytic study using cross-sectional was conducted in Department of Obstetrics and Gynecology, Sam Ratulangi University, in conjunction with the teaching hospital, Prof. Dr. R. D. Kandou General Hospital and the sister hospitals in Manado Hospital. Sixteen woman with normal pregnancy and sixteen others with severe preeclampsia who met the inclusion and exclusion criteria, were tested for lipid profile and ET-1. The serum was analyzed at Prodia Laboratory, Manado. The ET-1 level was examined using ELISA (R&amp;D Systems, Inc., Minneapolis, MN 55413, USA). The data obtained was analyzed using SPSS software version 20.0.</p> <p><strong>Main Outcome Measures: </strong>The comparison and correlation of lipid profile and endothelin-1 (ET-1) plasma level in normal and severe preeclamptic pregnancy.</p> <p><strong>Results:</strong> Higher cholesterol total, triglyceride, VLDL, ET-1 level were found in severe preeclampsia group. Also, there was a significant correlation between the ET-1 and the triglyceride (r=0589, p=0.016) and VLDL (r=0590, p=0.016) in the normal pregnancy group. In the severe preeclampsia group, there was no significant correlation between the two variables (p&gt;0.05).</p> <p><strong>Conclusion:</strong> There are elevated levels of triglycerides, VLDL and endothelin-1 in the incidence of severe preeclampsia compared with normotensive. This is a small and preliminary observational study, which shows that the older the age and parity the probability of preeclampsia increases and the more ET-1 is produced. But an elevation of the lipid profile is also observed without a proportional relationship with endothelin. This study suggests that lipids are involved in endothelial damage in pre-eclampsia without any relationship between them.</p> John Wantania Yosiana Wijaya Anastasia Lumentut Frans Wantania Bill Harman Billy Kepel Fransiskus Limono ##submission.copyrightStatement## 2021-04-20 2021-04-20 7 16