The Correlation of the Lipid Profile and Endothelin-1 with Severe Preeclampsia

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John Wantania
Yosiana Wijaya
Anastasia Lumentut
Frans Wantania
Bill Harman
Billy Kepel
Fransiskus Limono


Aims: To determine the relationship of lipid profile and Endothelin-1 (ET-1) in a severe preeclamptic pregnancy.

Study Design: An observational analytic study using cross-sectional was conducted in Department of Obstetrics and Gynecology, Sam Ratulangi University, in conjunction with the teaching hospital, Prof. Dr. R. D. Kandou General Hospital and the sister hospitals in Manado Hospital. Sixteen woman with normal pregnancy and sixteen others with severe preeclampsia who met the inclusion and exclusion criteria, were tested for lipid profile and ET-1. The serum was analyzed at Prodia Laboratory, Manado. The ET-1 level was examined using ELISA (R&D Systems, Inc., Minneapolis, MN 55413, USA). The data obtained was analyzed using SPSS software version 20.0.

Main Outcome Measures: The comparison and correlation of lipid profile and endothelin-1 (ET-1) plasma level in normal and severe preeclamptic pregnancy.

Results: Higher cholesterol total, triglyceride, VLDL, ET-1 level were found in severe preeclampsia group. Also, there was a significant correlation between the ET-1 and the triglyceride (r=0589, p=0.016) and VLDL (r=0590, p=0.016) in the normal pregnancy group. In the severe preeclampsia group, there was no significant correlation between the two variables (p>0.05).

Conclusion: There are elevated levels of triglycerides, VLDL and endothelin-1 in the incidence of severe preeclampsia compared with normotensive. This is a small and preliminary observational study, which shows that the older the age and parity the probability of preeclampsia increases and the more ET-1 is produced. But an elevation of the lipid profile is also observed without a proportional relationship with endothelin. This study suggests that lipids are involved in endothelial damage in pre-eclampsia without any relationship between them.

lipid profile, endothelin-1, preeclampsia.

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How to Cite
Wantania, J., Wijaya, Y., Lumentut, A., Wantania, F., Harman, B., Kepel, B., & Limono, F. (2021). The Correlation of the Lipid Profile and Endothelin-1 with Severe Preeclampsia. Asian Research Journal of Gynaecology and Obstetrics, 5(2), 7-16. Retrieved from
Original Research Article


Angsar MD, Ilmu Kebidanan Sarwono Prawiroharjo. PT Bina Pustaka Sarwono Prawirohardjo, Jakarta; 2016.

Trends in maternal mortality: 2000 to 2017: estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division. Geneva: World Health Organization; 2019.

Badan Kependudukan dan Keluarga Berencana Nasional, Survei Demografi dan Kesehatan Indonesia 2017, Badan Pusat Statistik, Jakarta; 2017.

Kementrian Kesehatan RI, Profil Kesehatan Indonesia Tahun 2013, Kementerian Kesehatan Republik Indonesia, Jakarta; 2019.

W.H.O., WHO Recommendations for calcium supplementation before pregnancy for prevention of pre-eclampsia and its complication, World Health Organization, Geneva; 2020.

Wibowo N, Irwinda R, Frisdiantiny R, Karkata MK, Mose JC, Chalid M, et al. Pedoman nasional pelayanan kedokteran: diagnosis dan tatalaksana preeklampsia, Kementrian Kesehatan Republik Indonesia, Jakarta; 2018.

Saleh L, Verdonk K, Visser W, Meiracker AV, Danser AHJ. The emerging role endothelin-1 in the pathogenesis of preeclampsia. Therapeutic Advances in Cardiovascular Disease. 2015;10(5):282– 293.

Brown MA, Magee LA, Kenny LC, Karumanchi SA, Mc Carthy FP, Saito S, et al. The hypertensive disorder of pregnancy: ISSHP classification, diagnosis & management recommendations for international practice. Pregnancy Hypertension. 2018;13:291-310.

Fisher SJ. Why is Placentation abnormal in preeclampsia? Am J Obstet Gynecol. 2015;S115-S112.

Karumanchi SA. Angiogenic factors and preeclampsia. Hypertension. 2016;67: 1072-1079.

Flint EJ, Cerdeira AS, Redman CW, Vatish M. The role of angiogenic factors in the management of preeclampsia. AOGS. 2019;98:700-707.

Granger JP, Spradley FT, Bakrania BA. The endothelin system: A critical player in pathophysiology of preeclampsia. Current Hypertension Rep. 2018;20(4): 32.

Barton M, Yanagisawa M. Endothelin: 30 years from discovery to therapy in clinical hypertension: 20 AHA Journal. 2019; 1232-1265.

Cunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS, Hoffman BL, et al. William obstetrics, twenty fifth ed., McGraw Hill, New York; 2018.

Winardo DS, Wantania JE, Mongan SP. Correlation between body mass index and lipid profile in second trimester with the incidence of hypertension in third trimester. Indonesia J Obstet Gynecol. 2019;34- 43.

Prasetyo A, Wantania JE, Suparman E. Correlation between body mass index and lipid profile in second trimester with the incidence of hypertension in third trimester. Indonesia J Obstet Gynecol. 2019;80- 85.

Saleh L, Danser JAH, Meiracker AHV. Role of Endothelin in Preeclampsia and Hypertension following antiangiogenesis treatment. Current Opinion in Nephrology and Hpertension. 2016;94-99.

Miller DA. Current diagnosis and treatment obstetrics and gynecology, tenth ed., McGraw Hill, New York; 2007.

Tesfa E, Nibret E, Munshea A. Maternal lipid profile and risk of preeclampsia in African pregnant women: A systematic review and meta- analysis. Journal Plos One. 2020;3.

Alahakoon TI, Medbury HJ, Williams H, Lee VW. Lipid profiling in maternal and fetal circulations in preeclampsia and fetal growth restriction a prospective case control observational study. BMC Pregnancy and Childbirth; 2020.

Jeyabalan A, Hubel CA, Roberts JM, Metabolic syndrome and preeclampsia, in: Taylor RN, Roberts JM, F. G. Cunningham, M. D. Lindheimer (Eds.), Chesley’s hypertensive disorders in pregnancy. Elsevier, London. 2009;133-51.

Sainani G, Maru V, Mehra A. Role of circulating endothelin-1 and tissue immunoreactivity in coronary artery disease. Medical Update; 2011.

Cardillo C, Kilcoyne CM, Cannon RO, Panza JA. Increased activity of endogenous endothelin in patients with hypercholesterolemia. J Am Coll Cardiol. 2000;36(5):1483-8.

Senol S, Akar I, Kargϋn K, Bayram A, Kara M, Secen O. Endothelin-1 gene polymorphism in preoperative myocardial infarction with /or without coronary artery bypass graft. Int J Hum Genet. 2014;14: 183-7.

Jenkins HN, Gonzales OR, Gilbert Y, Speed JS. Endothelin 1 in the pathophysiology of obesity and insulin resistance. Obesity Reviews. 2020;21:1-9.

Rapoport RM, Merkus D. Endothelin 1 regulation of Exercise Induced changes in flow: Dynamic regulation of vascular tone. Frontiers in Pharmacology. 2017;8:517: 1-9.

Ellatif MA, Assiri AS, Patel A, Eldein EM, Marzouki AA, Hamoudah MF, et al. The impact of high altitude on endothelial dysfunction of cardiovascular patients in Saudi Arabia: A biochemical study. American Journal of Medicine and Medical Sciences. 2014;4:79-86.

Coffey CG. Issue in the intepretation of serum endothelin levels in preeclamsia. Medical Hypothesis. 2019;1-7.