Risk Factors of Premature Rupture of the Membranes: Case Control Study

Salwa Benkia *

Department of Obstetrics and Gynecology, Benghazi Medical Center, Faculty of Medicine, University of Benghazi, Libya.

Nagat Bettamer

Department of Obstetrics and Gynecology, Al-Jamhoria Hospital, Faculty of Medicine, University of Benghazi, Libya.

Amna Attia Fadel

Department of Obstetrics and Gynecology, Benghazi Medical Center, Faculty of Medicine, University of Benghazi, Libya.

Enas R. Haleis

Department of Obstetrics and Gynecology, Benghazi Medical Center, Faculty of Medicine, University of Benghazi, Libya.

Tamadur Abdelnabi Abubakr

Benghazi Medical Center, Libya.

*Author to whom correspondence should be addressed.


Background: premature rupture of the membranes is a common condition with large contribution to preterm delivery and serious maternal and fetal morbidities. Aims: To investigate the risk factors of preterm premature rupture of membrane.

Methods: Case–control study included a review of records of sample cases delivered in Benghazi medical center during the year 2021. Statistical analysis was done using SPSS 23.0 with appropriate tests.

Results: A total of 120 participants were enrolled with 60 patients in each group. Maternal age was statistically significant only when considering categories. The rate of mothers in advanced maternal age was in case group,23.3% and for the control group, 43.3%. Also, a higher proportion of nullipara among a group of cases; 30.0% and Control; 13.3%, higher rate of mothers with previous caesarean was found among case group (31.7% against 10.0%), vaginal discharge was reported among all of cases (100.0%) while rate among controls was only 45.0% and high CRP was reported only among case group in a proportion of 23.3% but not among the control group. Those differences were all statistically significant. Blood group and Rhesus factor, history of abortion among controls, urinary tract infection, early pregnancy bleeding and male fetus had statistically insignificant differences.

Conclusion and Recommendations: Premature rupture of the membranes is associated with primiparity, history of vaginal discharge and clinical as well as laboratory manifestations of inflammation and further multicenter prospective study to verify outcomes of premature rupture of membranes are recommended.

Keywords: Risk factors of premature rupture, preterm prelabor rupture, genital infections, maternal inflammatory, prevent preterm birth, preterm births

How to Cite

Benkia, S., Bettamer , N., Fadel , A. A., Haleis , E. R., & Abubakr , T. A. (2024). Risk Factors of Premature Rupture of the Membranes: Case Control Study. Asian Research Journal of Gynaecology and Obstetrics, 7(1), 94–105. Retrieved from https://journalarjgo.com/index.php/ARJGO/article/view/214


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