Quality of Life of Patients with Interstitial Cystitis and It's Treatment: Literature Review

Huda Khalid Almayouf

Obstetric and Gynecology Consultant, Maternity Hospital, King Saud Medical City, Riyadh, Saudi Arabia.

Mathab Ali Jarad *

Obstetric and Gynecology Resident, Maternity Hospital, King Saud Medical City, Riyadh, Saudi Arabia.

Hassan Mayudh Almalki

Obstetric and Gynecology Resident, Maternity Hospital, King Saud Medical City, Riyadh, Saudi Arabia.

Saad Khaleel Alonze

Obstetric and Gynecology Resident, Maternity Hospital, King Saud Medical City, Riyadh, Saudi Arabia.

*Author to whom correspondence should be addressed.


Background: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition characterized by pelvic discomfort, frequent urination, and urine urgency. It negatively affects productivity, emotions, sleep, and mobility.

Aim: To assess the impact of interstitial cystitis on patients' quality of life (QoL) and examine strategies for its improvement.

Methods: We conducted a systematic review of studies published between 2014 and 2022, using PubMed and Google Scholar databases. We focused on medical therapies and their effects on QoL in interstitial cystitis patients. Inclusion criteria required full-text publications.

Results: Among 100 identified articles, only eight met the inclusion criteria. Two were cross-sectional studies, and three were retrospective studies. The total number of patients included in the studies was 4814, all diagnosed with IC/BPS.

Conclusion: Interstitial cystitis significantly impacts the quality of life, particularly in women. The most prevalent symptoms reported by IC/BPS patients are pain/discomfort, frequency and urgency of urination, and anxiety/depression. Treatment with Hyaluronic acid (HA) plus chondroitin sulfate (CS) appears to be comparable in effectiveness to Dimethyl sulfoxide (DMSO), with a potentially better safety profile.

Keywords: Quality of life, QoL, patients, interstitial cystitis, pain and IC/BPS

How to Cite

Almayouf , Huda Khalid, Mathab Ali Jarad, Hassan Mayudh Almalki, and Saad Khaleel Alonze. 2023. “Quality of Life of Patients With Interstitial Cystitis and It’s Treatment: Literature Review”. Asian Research Journal of Gynaecology and Obstetrics 6 (1):160-66. https://journalarjgo.com/index.php/ARJGO/article/view/182.


Download data is not yet available.


Fall M, Baranowski AP, Elneil S et al. EAU guidelines on chronic pelvic pain. Eur. Urol. 2010;57:35–48.

Nickel JC. Interstitial cystitis- An elusive clinical target? J. Urol. 2003;170:816–7.

Birder LA. Pathophysiology of interstitial cystitis. International Journal of Urology. 2019;26:12-5.

Hanno PM. Painful bladder syndrome/ interstitial cystitis and related disorders. In: Wein AJ, Novick KL, Partin AW, Peters CA (eds). Campbell-Walsh Urology. W.B. Saunders Company, Philadelphia. 2007; 330–70

Lugendorf SK, Kreder KH, Rothrock NE, Ratliff TL, Zimmerman B. Stress and symptomatology in patients with interstitial cystitis: A laboratory stress model. J. Urol. 2000;164:1265–9.

Pierce AN, Christianson JA. Stress and chronic pelvic pain. Prog. Mol. Biol. Transl. Sci. 2015;131:509–35.

Vasudevan V, Moldwin R. Addressing quality of life in the patient with interstitial cystitis/bladder pain syndrome. Asian Journal of Urology. 2017;4(1):50-4.

Barofsky I. Can quality or quality of life be defined? Qual Life Res. 2012;21:625–631.

Felce D, Perry J. Quality of life: Its definition and measurement. Research in Developmental Disabilities. 1995;16(1):51-74.

WHOQOL. World Health Organization. measuring quality of life. Programme on mental health: Division of Mental Health and Prevention of Substance Abuse. 1997;1–10.

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. PLoS Medicine. 2009;6(7):e1000100.

Ko KJ, Lim J, Yu J, Kang D, Cho J, Lee KS. The impact of hunner lesion-type interstitial cystitis/bladder pain syndrome on health-related quality of life and the effects of transurethral ablation. Quality of Life Research. 2022;31(11):3221-8.

Borrego-Jimenez PS, Flores-Fraile J, Padilla-Fernández BY, Valverde-Martinez S, Gómez-Prieto A, Márquez-Sánchez MT, Mirón-Canelo JA, Lorenzo-Gómez MF. Improvement in quality of life with pelvic floor muscle training and biofeedback in patients with painful bladder syndrome/ interstitial cystitis. Journal of Clinical Medicine. 2021;10(4):862.

Volpe KA, Mandelbaum R, Rodriguez LV, Özel BZ, Rolston R, Dancz CE. Does obtaining a diagnosis of interstitial cystitis/ bladder pain syndrome improve symptoms or quality of life? A cross-sectional questionnaire-based study. Female Pelvic Medicine & Reconstructive Surgery. 2021; 27(5):328-33.

Wang JW, Liu JC, Meng LF, Zhang W, Liu XD, Zhang YG. Quality of life and related factors in patients with interstitial cystitis/bladder pain syndrome. Beijing da xue xue bao. Yi xue ban= Journal of Peking University. Health Sciences. 2021; 53(4):653-8.

Troxel WM, Booth M, Buysse DJ, Elliott MN, Suskind AM, Clemens JQ, Berry SH. Sleep disturbances and nocturnal symptoms: relationships with quality of life in a population-based sample of women with interstitial cystitis/bladder pain syndrome. Journal of Clinical Sleep Medicine. 2014;10(12):1331-7.

Cervigni M, Sommariva M, Tenaglia R, Porru D, Ostardo E, Giammò A, Trevisan S, Frangione V, Ciani O, Tarricone R, Pappagallo GL. A randomized, open‐label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis. Neurourology and Urodynamics. 2017;36(4):1178-86.

Zambon* J, Hemal K, Evans R, Badlani G, Walker S, Plair A, Smith W, Parker-Autry C, Matthews C. MP47-18 simple cystectomy for female patients with refractory interstitial cystitis/bladder pain syndrome: Is there any long-term impact on quality of life, body image, and sexual function?. The Journal of Urology. 2019; 201:e695-e695.

Pinto RA, Costa D, Morgado A, Pereira P, Charrua A, Silva J, Cruz F. Intratrigonal onabotulinumtoxinA improves bladder symptoms and quality of life in patients with bladder pain syndrome/interstitial cystitis: A pilot, single center, randomized, double-blind, placebo controlled trial. The Journal of Urology. 2018;199(4):998-1003.

Bo K, Frawley HC, Haylen BT, Abramov Y, Almeida FG, Berghmans B, Bortolini M, Dumoulin C, Gomes M, McClurg D, Meijlink J. An international urogynecological association (iuga)/ international continence society (ics) joint report on the terminology for the conservative and nonpharmacological management of female pelvic floor dysfunction. International Urogynecology Journal. 2017;28(2):191-213.

Nickel JC, Tripp DA, Pontari M, et al. Psychosocial phenotyping in women with interstitial cystitis/painful bladder syndrome: A case control study. J Urol. 2010;183:167-172.

Lai H, Gardner V, Vetter J, Andriole GL. Correlation between psychological stress levels and the severity of overactive bladder symptoms. BMC Urology. 2015; 15(1):1-7.

Romão AP, Gorayeb R, Romão GS, Poli‐Neto OB, Dos Reis FJ, Rosa‐e‐Silva JC, Nogueira AA. High levels of anxiety and depression have a negative effect on quality of life of women with chronic pelvic pain. International Journal of Clinical Practice. 2009;63(5):707-11.

Norus T, Fode M, Nordling J. Ileal conduit without cystectomy may be an appropriate option in the treatment of intractable bladder pain syndrome/interstitial cystitis. Scandinavian Journal of Urology. 2014; 48(2):210-5.

McCahy PJ, Styles RA. Prolonged bladder distension: Experience in the treatment of detrusor overactivity and interstitial cystitis. European Urology. 1995;28:325-7.

Ware Jr JE. SF-36 health survey update. Spine. 2000;25(24):3130-9.

Rössberger J, Fall M, Peeker R. Critical appraisal of dimethyl sulfoxide treatment for interstitial cystitis discomfort, side-effects and treatment outcome. Scandinavian Journal of Urology and Nephrology. 2005;39(1):73-7.

Steinhoff G. The efficacy of chondroitin sulphate in treating interstitial cystitis. European Urology Supplements. 2003; 2(4):14-6.

Istek A, Gungor Ugurlucan F, Yasa C, Gokyildiz S, Yalcin O. Randomized trial of long-term effects of percutaneous tibial nerve stimulation on chronic pelvic pain. Archives of Gynecology and Obstetrics. 2014;290(2):291-8.